• Liver (parenchyma & fat metabolism) — Fatty degeneration, enlarged tender liver, right-sided weight; jaundiced tinge; dyspeptic bulimia with emaciation [Clarke], [Boericke].
• Heart & great vessels — Fatty heart with dilatation, soft weak/low-tension pulse, præcordial oppression and anginoid pains on exertion; arterio-sclerosis (capillary and arterial tension) [Clarke], [Farrington].
• Metabolism (pancreas–liver axis) — Glycosuria with thirst and polyuria; later albuminuria with oedema; “mal-oxidation” states [Hale], [Allen].
• Kidneys — Nephritis/albuminuria with casts; lumbar soreness; evening ankle oedema [Allen], [Clarke].
• Blood — Low hæmoglobin anæmia; pallor with palpitation, faintness, breathlessness; “oxygen hunger” [Boericke], [Clarke].
• Lungs — Chronic bronchitis/phthisical tendency with green or blood-streaked sputum, night sweats, hæmoptysis tendency; “cardiac asthma” from fatty heart [Hering], [Clarke].
• Nervous system — Neurasthenia, weak memory, insomnia driven by præcordial oppression/dyspnœa [Allen], [Clarke].
• Skin/trophic — Dry pruritic skin, indolent ulcers and boils in diabetics/cachectics; brittle nails, dull hair [Boericke], [Phatak].

• Rest; avoidance of exertion (heart/respiratory weakness) [Clarke].
• Warmth and warm drinks for gastric sinking and chest oppression [Boericke].
• Open, cool air in quiet settings (relieves congestive head and dyspnœa) [Clarke].
• Small, frequent feedings (bulimic emptiness abates briefly) [Hale].
• Sitting propped up during breathlessness; steady pace, no hurry [Boericke], [Clarke].

• Exertion, hurrying, stair-climbing → palpitation, dyspnœa, præcordial pain [Clarke], [Boericke].
• Night → cough, sweat, thirst; glycosuria/albuminuria more troublesome; insomnia [Allen], [Hering].
• Fatty or highly seasoned foods, alcohol; after meals: epigastric weight, hepatic discomfort [Clarke].
• Cold damp (chest, kidneys); wind/exposure in weak chests [Boger], [Hering].
• Mental strain, loss of sleep → head-rush, palpitations [Allen].

A drained, oxygen-hungry mood: mental dulness, poor grasp/recall, quick fatigue of attention; by night anxiety centred in the chest (“heart will fail”) with restless tossing until the pulse calms [Allen], [Clarke], [Boericke]. Irritability from trivial effort; despondency in long degenerations (fatty heart/liver) [Clarke], [Farrington]. Children of diabetic diathesis: peevish, sleepless toward midnight, thirsty, with frequent urination [Allen].

Cerebral anaemia signs: heaviness, pressing band-like pain, occipital weight; vertigo on rising; pallid face; throbbing on the least effort—better cool air and quiet [Allen], [Clarke]. Headache in arterio-sclerosis: dull, compressive; screen-glare and hurry aggravate [Clarke], [Farrington]. Head rush and faintness after climbing (heart-brain circulation mismatch) [Clarke].

Dim sight on exertion; black specks; conjunctivae pale; orbital aching in anaemia; transient blur with palpitations [Allen], [Clarke].

Low humming with low blood state; “blank” momentary deafness on rising; cold ear-lobes in cachexia [Allen].

Dryness; crusting in diabetics; pale mucosa; occasional epistaxis from vascular fragility [Clarke].

Pale, sometimes sallow or puffy beneath eyes (renal); lips dry; anxious expression on slight effort; malar flush toward evening in chest-wasting states [Clarke], [Hering].

Dryness; metallic taste; tongue pale, mapped, or indented; aphthous spots in cachexia; thirst moderate to considerable (rises with glycosuria) [Allen], [Boericke].

Sensitive with anaemia; ache on cold air; grinding in exhausted adolescents (neurasthenic) [Allen].

Rawness with short teasing cough; must sip warm drinks, which soothe; hawks small green lumps or mucus streaked with blood [Hering], [Clarke].

Bulimia with emaciation—must eat little and often, yet grows thin. Gastric sinking, acidity, flatus; epigastric weight or dull pain after fats or rich food; eructation relieves head pressure [Hale], [Allen], [Clarke]. Nausea on exertion; appetite capricious in advanced cachexia [Boericke].

Right hypochondrial weight/tenderness (fatty liver); abdomen distended with wind; pale stools in hepatic drift; alternating constipation and relaxed stools with weakness [Clarke], [Allen].

Polyuria with glycosuria (thirst, dry mouth); later albuminuria with casts; lumbar soreness; ankle oedema by evening [Hale], [Allen], [Clarke]. Enuresis nocturna in weak, cachectic adolescents (clinical note) [Boericke].

Tendency to constipation with pale, offensive stools (bile-poverty); or relaxed mucous stools with prostration in chest-wasting states [Allen], [Hering]. Haemorrhoids from portal stasis in fatty liver [Clarke].

Sexual weakness—scanty erections, emissions with exhaustion; prostatic irritation with urethral burning; achy spermatic cords in diabetics/cachectics [Clarke], [Hale].

Menses scant/late with anaemia; climacteric flushes with palpitations and arterial tension; pruritus vulvae in diabetic states; milk scant in wasting mothers [Clarke], [Boericke].

Short breath, sighing; wants cool, still air; talking or emotion oppresses; fidgets to find easier posture (sits forward, elbows on knees) [Clarke].

Fatty degeneration and dilatation; soft, weak, rapid or low-tension pulse; praecordial anxiety; stitching or dull pains on slight effort; anginoid constriction in arterio-sclerotic subjects; palpitations at night [Clarke], [Farrington], [Boericke]. Pulse steadies with rest/quiet cool air.

Chronic bronchitis / phthisical tendency: green, sweetish or blood-streaked sputum; cough worse night; short wind on stairs; weight on sternum; haemoptysis tendency with night sweats [Hering], [Clarke]. “Cardiac asthma” from fatty heart—oppression on lying; must sit propped [Clarke], [Boericke]. Warm drinks and rest palliate.

Between-shoulders ache with cardiac weakness; lumbar soreness (renal); weary spine—standing aggravates [Allen].

Tremulous weakness; heavy legs; oedematous ankles evenings; burning soles at night (diabetic); calf cramps; cold hands/feet with head heat on exertion [Allen], [Phatak]. Effort at once flushes head, empties limb-muscle power.

Pale, dry; pruritus (especially diabetic); indolent ulcers, slow healing; boils in the debilitated; brittle nails; hair dull [Boericke], [Clarke]. In arterio-sclerosis, skin looks parchment-dry with poor turgor.

Unrefreshing; insomnia from praecordial oppression, cough, or burning soles; dozes after midnight when pulse quiets; dreams of exertion or choking [Hering], [Allen].

Anxious dreams of climbing or hurrying, breath fails; wakes with palpitation; dreams of bleeding or medical scenes in chest-wasting states (clinical) [Clarke].

Subfebrile evenings; night sweats in wasting chests; chilliness after small exertions; sweats on slight effort—little relief [Allen], [Hering].

Chill from motion or draft; heat subjective in chest/epigastrium; sweat easily, especially at night, without refreshment [Allen].

Aversion to heavy fats; craving for small, frequent simple meals; warm drinks soothe; alcohol/fatty foods aggravate heart-liver; sweets exacerbate glycosuria and itching [Hale], [Clarke].

A remedy of mal-nutrition and degeneration: anaemia with breathlessness, bulimia yet wasting, fatty liver/heart, arterio-sclerosis, glycosuria → albuminuria, wasting chest with green/blood-streaked sputum, night aggravations, and exertion intolerance. Relief from rest, warmth, small meals, quiet cool air; collapse follows hurry. The clinical melody is “oxygen hunger in a fatty frame” [Clarke], [Boericke], [Hale], [Allen].

Fatty degeneration (liver/heart) & arterio-sclerosis

• Phos. — Fatty change with haemorrhagic tendency, burning, craving cold drinks; more nervous irritability. Vanad. is paler, more bulimic-with-wasting, with arterial tension and weak heart [Kent], [Clarke].
• Aurum — High-pressure cardio-sclerosis with profound melancholy/suicidal gloom; Vanad. is more cachectic, “oxygen-starved,” less moral collapse [Farrington], [Clarke].
• Crat. — Myocardial tonic once failure is declared; Vanad. earlier in degenerative terrain (fatty drift, anaemia) [Farrington].
• Bar-m. — Vessel stiffness in elderly with mental decline; Vanad. has bulimia-emaciation, diabetic/albuminuric axis [Kent].
• Iod. — Rapid emaciation with heat and restless appetite; Vanad. less heat, more cardiac/hepatic fatty change [Kent].

Diabetes / albuminuria axis

• Uran-n. — Diabetes with post-prandial 1–2 h ulcer pain, harsher visceral destruction; Vanad. “softer,” nutritive/oxidative, with fatty liver/heart and arterial tension [Hale], [Clarke].
• Phos-ac. — Diabetes from grief/mental apathy; less degenerative organ picture [Farrington].
• Syzygium — Sugar-lowering palliative; lacks degenerative breadth of Vanad. [Clarke].
• Ars. — Burning, anxiety, restlessness; strong heat need; less hepatic fatty stamp; great prostration [Kent].

Wasting chest (green/blood-streaked sputum, night sweats)

• Phos. — Bright-red haemoptysis, burning chest, open-air desire; Vanad. sputum greenish or streaked; more cardiac weakness [Clarke], [Hering].
• Ars. — Burning respiration, after-midnight aggravation; Vanad. less terror, more degeneration with anaemia [Kent].
• Ant-t. — Rales, drowsiness, suffocation; Vanad. is leaner, more cachectic with arterial/diabetic overtones [Boger].
• Tub. — Rapid wasting with changeability; Vanad. carries a steadier degenerative heart-liver axis [Tyler].

Anaemia with dyspnœa and palpitation

• Ferr. — Flushing pallor, throbbing carotids; Vanad. adds bulimia + emaciation, fatty viscera, green sputum [Clarke].
• Cinch. — Anaemia after losses, gas bloat; less arterio-sclerosis and fatty heart [Farrington].

Bulimia with emaciation

• Iod. — Hot, restless, ravenous; Vanad. cooler, breathless, fatty viscera.
• Nat-m. — Emaciation despite eating, but with dryness/grief picture; Vanad. is cardio-hepatic and diabetic [Kent], [Clarke].

• Complementary: Phos. (fatty/haemorrhagic states), Crat. (myocardial support), Phos-ac. (apathy in convalescence/diabetes) [Farrington], [Clarke].
• Follows well: Ferr., Cinch. after post-haemorrhagic anaemia when degenerative drift begins [Clarke].
• Precedes well: Uran-n. when the case hardens into overt diabetes with visceral degeneration and ulcer rhythm [Hale].
• Related: Aurum, Bar-m. in arterio-sclerosis; Iod. in rapid wasting; Ars./Phos. in chest wasting—select by heat, haemorrhage, and mental colour [Kent], [Farrington].
• Adjuncts (clinical): Rest, graded exertion, small frequent meals, low alcohol/fats, warm beverages—measures that echo Vanad. modalities and often unlock sleep [Clarke], [Boericke].

• Fatty heart with dyspnœa on slight effort, soft weak pulse, praecordial weight: Vanad. 6C–30C once–twice daily for a few days; space as breath and sleep improve; consider Crat. later for sustained myocardial tone [Clarke], [Farrington].
• Fatty liver / bulimic dyspepsia with emaciation, right hypochondrial weight: Vanad. 6C t.d.s. for 3–5 days, then p.r.n.; simple warm diet (soups, broths), avoid alcohol/fats [Boericke], [Clarke].
• Diabetes tending to albuminuria in a pale, breathless patient with ankle oedema: Vanad. 30C nocte; compare Uran-n. if ulcer rhythm or severe glycosuria dominates; monitor ankles and energy (clinical) [Hale], [Clarke].
• Wasting bronchitis/phthisical tendency (green or blood-streaked sputum, night sweats, exertional dyspnœa): Vanad. 30C nightly; warm drinks, graded airings; compare Phos./Ars. as picture shifts [Hering], [Clarke].
• Anaemia with insomnia and head-pressure from minimal effort: Vanad. 6C evening for several nights; encourage early bed and small warm feedings—often steadies pulse and sleep [Allen], [Boericke].
• The colour of sputum (greenish with streaks) alongside soft pulse and breathless bulimia is often decisive.
• In arterio-sclerosis with low-tension pulse and fatigable myocardium, Vanad. can precede Crat.
• In diabetic states drifting to albuminuria, Vanad. suits the cachectic, breathless patient better than sugar-centric remedies alone.
• In fatty liver with right-sided weight and bulimic dyspepsia, it restores appetite quality and ease rather than quantity.

Mind

• Mind—Dullness—anaemia, from; concentration difficult. [Allen], [Clarke]
• Mind—Anxiety—heart symptoms, about—night. [Clarke], [Boericke]
• Memory—weak—exertion aggravates. [Allen]

Head

• Head—Heaviness—cerebral anaemia—rising, on—vertigo. [Allen]
• Head—Pain—compressive—arterio-sclerosis—exertion aggravates. [Clarke], [Farrington]
• Head—Congestion—on slight effort—cool air ameliorates. [Clarke]

Eyes

• Vision—dim—on exertion—black specks. [Allen]

Stomach / Abdomen

• Appetite—ravenous—emaciation, with. [Hale], [Clarke]
• Stomach—sinking—emptiness—better small frequent meals. [Hale]
• Liver—fatty degeneration—tenderness/right hypochondrium weight. [Clarke], [Boericke]

Urinary

• Urine—sugar—glycosuria—polyuria with thirst. [Hale], [Allen]
• Urine—albumen—casts—oedema of ankles—evening. [Allen], [Clarke]
• Enuresis—night—weak, cachectic adolescents. [Boericke]

Chest / Heart / Respiration

• Cough—chronic—green or blood-streaked expectoration—night worse. [Hering], [Clarke]
• Lungs—haemoptysis—wasting states. [Clarke]
• Heart—fatty degeneration/dilatation—palpitation from the least exertion. [Clarke], [Boericke]
• Pulse—weak—soft—low tension. [Boericke]
• Respiration—shortness of breath—exertion aggravates—sitting up ameliorates. [Clarke]

Generalities / Blood

• Generalities—Anaemia—haemoglobin low—breathlessness. [Clarke], [Boericke]
• Generalities—Emaciation—despite eating often. [Hale]
• Generalities—Exertion aggravates—palpitation/dyspnœa. [Clarke]
• Generalities—Night—aggravation—sweats, cough, anxiety. [Hering]

Skin

• Skin—Pruritus—diabetic—dry skin. [Boericke], [Phatak]
• Ulcers—indolent—cachectic/diabetic—slow healing. [Clarke]

Hale, E. M. — New Remedies (var. eds., 1864–1891): metabolic notes (glycosuria), nutritive/oxidative claims, clinical spheres.
Allen, T. F. — Encyclopaedia of Pure Materia Medica (1874–79): provings/clinical observations—anaemia, cachexia, chest and renal features.
Hering, C. — The Guiding Symptoms of Our Materia Medica (1879–91): wasting-chest states, night sweats, green/blood-streaked sputum.
Hughes, R. — A Manual of Pharmacodynamics (1880): historical toxicology/physiology; “oxygenation” and anti-fatty claims in context.
Clarke, J. H. — A Dictionary of Practical Materia Medica (1900): fatty heart/liver, arterio-sclerosis, diabetes/albuminuria, general portrait.
Boericke, W. — Pocket Manual of Homœopathic Materia Medica (1901): concise keynotes—haemoglobin, fatty degeneration, diabetes, bronchitis/phthisis.
Farrington, E. A. — Clinical Materia Medica (1887): comparisons with Phos., Aurum, Crataegus; cardio-sclerosis context.
Boger, C. M. — Synoptic Key of the Materia Medica (1915): generalities—exertion aggravates, cold damp, degenerative miasm.
Kent, J. T. — Lectures on Homœopathic Materia Medica (1905): miasmatic colouring; fatty/arterial degenerations and differentials.
Tyler, M. L. — Homœopathic Drug Pictures (1942): comparative hints in chest wasting and cardio-vascular weakness.
Nash, E. B. — Leaders in Homœopathic Therapeutics (1907): aphorisms on anaemia/degeneration (comparative context).
Dunham, C. — Lectures on Materia Medica (1878): hygienic adjuncts (rest, small feedings, graded exertion) consistent with remedy modalities.