A drug-layer remedy for the age of antibiotics. The story is recurring: before antibiotics the patient suffered a limited catarrh; thereafter, each course suppresses the discharge briefly but widens the field of disturbance—allergy rises, gut flora derange, thrush appears, and vitality sinks into a fog. The psyche becomes a little brittle—irritable, flat, and wary of new medicines—while the organism oscillates between blocked and leaking: stopped nose vs post-nasal drip, dry skin vs damp intertrigo, constipated mornings vs loose afternoons. The hallmark is periodicity linked to antibiotic use and dietary sugar/yeast: sweets tempt, then punish; yeast-rich foods and damp, mouldy places set the cycle rolling again. The patient is better in cool, fresh air, better once a physiological outlet returns (a proper nasal or vaginal discharge, a regular stool), and worse in warmth and humidity, worse at night, worse after suppressive measures layered upon one another (steroids + antibiotics). [Vithoulkas], [Morrison], [Sankaran], [Julian].

In Sankaran’s language this is the drug miasm: an internal loss of autonomy where external chemical forces dictate function; the person feels contaminated or dependent on interventions and simultaneously over-reactive to them. Vithoulkas frames it as iatrogenic chronic disease—once the remedy that neutralises the causal agent is given, the case often “unfreezes”, allowing a constitutional to act. Clinically, Penicillinum is therefore chosen not by a flamboyant keynote but by a clean history: repeated antibiotic exposure → persistent hypersensitivity + dysbiosis + recurrent catarrh/candida, with modalities worse damp/warmth/sweets/night, better cool air, diet simplification, restoration of discharge. This essence clarifies differentiation from Cand-alb. (pure yeast terrain without clear antibiotic trigger), Nux-v. (drug irritability but loves warmth/stimulants), and Sulph. (heat and itch without the antibiotic-driven oscillation). When accurate, Penicillinum tends to produce soft, systemic shifts—sleep steadies, itch quietens, stool regularises, and the person thinks more clearly—signs that the drug layer has loosened and the deeper remedy picture is coming into view. [Vithoulkas], [Morrison], [Sankaran], [Julian], [Shore].