• Pancreas–Carbohydrate metabolism — Glycosuria/diabetes mellitus with excessive thirst, copious pale urine, weight loss, and exhaustion, especially in anxious, chilly subjects with burning gastric symptoms [Clarke], [Boericke], [Phatak].
• Kidneys (glomerular–tubular) — Albuminuria, casts, oedema about ankles, nocturnal urination, and lumbar soreness; post-scarlatinal and chronic nephritic states [Hering], [Boger], [Clarke].
• Heart & great vessels — Palpitations, weak, compressible pulse, anginoid oppression with asthma; cardiac dyspnoea in anaemia or renal disease [Clarke], [Boericke].
• Lungs–bronchi — Nocturnal asthma, wheezing, tightness < after midnight, < lying, with chilliness and a need for warm coverings though fresh air at the window is craved during oppression [Boger], [Phatak], [Clarke].
• Stomach & upper GI — Gastric irritability: nausea, vomiting of food or water soon after taking it, burning epigastric pains, and thirst for frequent small sips [Allen], [Clarke].
• Skin — Dry, scaly eczema, fissures and ulcers that burn, heal slowly; pruritus worse warmth of bed [Boericke], [Hering].
• Eyes (retinal–vascular) — Albuminuric/diabetic retinopathy analogue: misty sight, black spots, photophobia in renal/diabetic cases [Clarke], [Boger].
• Blood & nutrition — Anaemia, sallow pallor, easy chill, prostration disproportionate to exertion; low-grade cachexy with Arsenicum colouring [Kent], [Nash].
• Mucous membranes (nose–throat) — Dryness with burning coryza, thin acrid discharge excoriating the alae; recurrent “winter catarrh” in weakly, diabetic or renal patients [Clarke], [Phatak].

• Warmth in general; warm drinks — Soothes burning pains and gastric distress; the Arsenicum trait persists in this salt [Allen], [Boericke].
• Fresh air at the window during oppression — Though chilly, the patient craves air when asthmatic tightness mounts; propped at an open sash [Clarke], [Boger].
• Propped sitting / head high — Relieves orthopnoea, cardiac dyspnoea, and nocturnal asthma [Clarke].
• Frequent small sips of water — Eases thirst and nausea; large draughts aggravate [Allen].
• Gentle, slow walking — Circulation steadies; palpitations and anxiety abate somewhat (convalescent type) [Clarke].
• Careful, light diet — Easily digested foods reduce gastric burning and vomiting [Boericke].
• Regular, free urine and stool — When emunctories act, headache and oppression lessen [Boger].
• After reassuring company/consolation — Anxiety and restlessness quiet down; will sleep [Kent].
• Warm applications to chest/epigastrium — Temporarily dulls burning and tightness [Clarke].
• Evening nap before midnight — Some attacks delay if there is early rest; once after midnight, aggravation predominates [Phatak].

• After midnight (1–3 a.m.) — Asthma, anxiety, restlessness, burning pains and diarrhoea intensify—Arsenicum time [Hering], [Kent].
• Cold air on the chest; draughts — Tightness, wheeze, and cough aggravated even though the patient seeks air for relief [Clarke], [Boger].
• Lying flat; least exertion; ascending — Orthopnoea, palpitations; must sit up [Clarke].
• Fatty, cold, or iced foods/drinks — Gastric burning, vomiting, and looseness follow [Allen], [Boericke].
• Suppression of sweat or catarrh — Renal and cardiac oppression increase; skin eruptions burn more when checked [Boger], [Hering].
• Heat of room / sun (in some sodium types) — Headache, dryness, epistaxis or collapse in close rooms; contrasts with desire for warm applications locally [Clarke], [Kent].
• Worry, business cares, and solitude — Anxiety grips the chest; palpitations and insomnia recur [Kent], [Nash].
• Cold, damp weather — Catarrhs, oedema, wheeze, and renal aching worse [Clarke], [Boger].
• Large draughts of water — Vomited promptly; prefers frequent small sips [Allen].
• Morning on rising (diabetics) — Weakness, giddiness, and polyuria press until food and warmth restore [Clarke].
• Before menses (women) — Palpitations and dyspnoea increase with pallor and chill [Farrington].
• After sleep (some complaints) — Wakes with tightness, dryness, and thirst, especially towards early morning [Phatak].

Anxiety centres in the health and the heart, with a restless, chilly misery that rises towards and after midnight; the patient wants company and reassurance but is too exhausted to talk much [Kent], [Hering]. Fear of suffocation accompanies nocturnal asthma; when the window is opened the oppression lessens, though the cold air may simultaneously chill him—this paradox reflects the cross-modality noted above. Fastidious, careful, easily worried over small domestic or business details, he lies awake counting the pulse and planning around his weakness [Kent], [Clarke]. Depression follows long illness: a sodic dryness of emotion, weeping when alone yet refusing consolation at the peak of irritability, shifts into gratitude once quieted—Natrum–Arsenicum polarity. Fear of poverty and of the future is common in diabetics and renal patients who experience prostration out of proportion to visible disease [Nash]. Relief in mind often coincides with a free urinary flow or warm drink that eases the gastric burning; the psyche follows the soma’s releases (echoing Better For). After bad nights he is indifferent, tremulous, and chilly until the day warms, then again anxious at dusk.

Headache is fronto-vertex, pressing, with scalp tenderness and burning heat, worse in warm rooms or sun, and worse after midnight when chest oppression wakens him [Clarke], [Kent]. Dizziness occurs on rising, with darkness before eyes in anaemic or diabetic subjects; fresh air relieves if the head is wrapped warmly. The face is sallow, pinched, lips pale; there may be a bluish tinge about the mouth in cardiac dyspnoea. Neuralgic twinges alternate temples, worse draught; better warmth and rest. Headache lightens after a free urination or a small hot drink, tying to Generalities. Compare Nat-m. (sun-headache with bursting and tearfulness) and Ars. (burning, midnight, restlessness): Nat-ar. sits between, with dryness and anaemia conspicuous [Clarke], [Boger].