Indigofera tinctoria

Indigo is the famed blue dye obtained by fermenting the leaves of Indigofera spp., precipitating the indoxyl to indigo (C₁₆H₁₀N₂O₂). The crude plant contains indican (a glucose–indoxyl conjugate), which by enzymic hydrolysis and oxidation yields the insoluble blue pigment; traces of indigoid relatives (indirubin, indigo brown) accompany it [Hughes], [Clarke]. Physiologically, large quantities of the dye have little direct irritant action, yet in workers and experimental use one meets gastric disturbance, stubborn headaches, neurotic excitability, and pruriginous states—threads that appear in the homœopathic picture [Hughes], [Allen], [Clarke]. The mother tincture has been made from the prepared dye in trituration, or from the fresh plant, with potencies carried in the usual centesimal scale [Allen], [Clarke]. Clinical use has chiefly grown from observations in children—worm disorders with reflex nervous phenomena (cough, spasms, enuresis) and peculiar frontal headaches—placing Indigo among the minor but pointed remedies for gastrointestinal–neurotic reflexes [Hering], [Boericke], [Clarke].

Indigo’s pathogenesis rests on small provings and numerous [Clinical] confirmations culled by Allen and Hering: frontal headaches in bands or at the root of the nose; irritative, hacking or spasmodic coughs in nervous children; worm symptoms (pruritus ani, nose-picking, restless sleep, enuresis); spasmodic and hysteriform phenomena; abdominal colic with mucus and threadworms; and a notable modality from sweets aggravating stomach and nerves [Allen], [Hering], [Clarke], [Boericke]. [Proving] [Clinical]

Indigo lives where the bowel and the nerves converse. In the classic child, the centre is the rectum—threadworms kindle an intolerable itching and a vague, crawling unrest which propagates to the larynx as a tickling cough and to the head as a banded frontal pressure. The mind follows the gut: irritable, peevish, obstinate, and fretful under the smallest contrariety, then docile once the itching abates or after a stool. Sweets are the tinder: a cake or pastry in the afternoon, and evening finds the child more restless, scratching, coughing, and clutching the forehead; the night is broken by startings, cries, and often a wet bed. The modalities therefore are not decorative but diagnostic—worse night, warm rooms, sweets, and mental effort; better open air, cold sponging, lying on the abdomen for colic, and—most tellingly—after the passage of worms. This chain appears paragraph by paragraph in the pathogenesis and is clinically reliable [Hering], [Allen], [Clarke], [Boericke].
The kingdom signature (Leguminosæ) shows a functional, surface-reactive picture rather than deep destructive pathology. Miasmatically the remedy is psoric in its itch, restlessness, and fatigue, with sycotic recurrency (worms, mucus stools, habitual cough fits) and a faint syphilitic edge in the periodicity of headaches and spasms. Its pace is remittent; crises are brief but recurrent, tied to diet and bedtime. Compared with its neighbours, Indigo is smaller in range but precise in application: where Cina and Teucrium cover the brute worm business, Indigo is chosen by the nervous echo—tickling coughs, frontal band headaches, startings, enuresis—and by the dietary modality, sweets agg. Drosera and Corallium overshadow it in whooping-cough, yet Indigo will often end a lingering tickle in a wormy child. Spigelia is more neuralgic and left frontal; Gelsemium is more muscularly heavy; Chamomilla more pain-raging; Ignatia more psychogenic. Indigo’s portrait is homely and simple: a child who cannot bear the heat and closeness of the room, who picks the nose and scratches the anus, who coughs at night in little spasms with gagging, and who grows calm and clear-headed by the open window after the bowels have moved and the sweetmeats are put away. The practical lesson is as old as Hering’s: align remedy and regimen—cool air, bland diet, early sleep, hygienic care of the rectum—and the medicine shows quickly in quieter nights, a drier pillow, a brow relieved of its band, and a bed that stays dry till morning.

• Intestinal tract (small intestine, cæcum/rectum)—threadworm (oxyuris) irritation with pruritus ani, colic, and mucus stools; reflex coughs and spasms (see Rectum, Abdomen, Respiration). [Hering], [Clarke], [Boericke].
• Nervous system—reflex excitability from gastro-intestinal irritation: startings, twitchings, hysteriform fits; night terrors in children (see Mind, Sleep). [Allen], [Hering].
• Head (frontal root-of-nose region)—periodical pressing/banding headaches, worse mental effort and warmth of room; relieved in open air (see Head). [Allen], [Clarke].
• Respiratory mucosa—tickling laryngeal coughs, “whoop-like” spells in nervous children with worms; scant expectoration (see Respiration, Chest). [Clarke], [Boericke].
• Urinary bladder—nocturnal enuresis with worms or night-cough; irritable, weak sphincter (see Urinary, Sleep). [Hering], [Clarke].
• Skin and mucocutaneous margins—itching, especially anus and nose; urticarious prickle after sweets (see Skin, Nose, Rectum). [Hering], [Boericke].
• Eyes/ears by congestion—blackness before eyes and buzzing with the cardiac rushes during cough or fright (see Eyes, Ears). [Allen], [Clarke].
• Female pelvic reflexes—pruritus vulvæ and bearing-down in wormy girls; dysmenorrhœa with gastric irritability (see Female). [Clarke], [Boericke].

Irritability and peevishness dominate the Indigo child, who whines, strikes, or bursts into tears under the least contradiction, then repents quickly when the abdominal pain or itching abates; the temper swings are proportioned to the reflex irritation (Mind ↔ Abdomen/Rectum) [Hering], [Clarke]. Study or any mental effort brings an immediate heaviness and band-like pressure across the forehead, with fretfulness and a desire to be in the open air (this tallies with “worse mental effort; better open air”) [Allen], [Clarke]. Night makes them anxious and restless; they start at every sound, cry out in sleep, and are tormented by “something crawling,” an impression that vanishes when the bowels move or the itching is relieved (cross-link to Sleep/Rectum) [Hering]. Fear of the dark and of being alone appears in wormy subjects; they cling, then push the parent away in irritability—psoric alternation of dependence and aversion [Clarke], [Kent]. The adolescent Indigo picture shows hypochondriacal brooding over health, especially digestion and the heart’s beats, which grow noisy during cough or emotion (Mind ↔ Chest/Heart/Ears); quiet air calms both mind and chest [Clarke]. Fright and excitement precipitate cough and spasmodic twitchings; afterwards the child is dull, obstinate, and sleepy, yet cannot sleep for the itching (Mind/Sleep) [Hering]. The remedy has a secondary sadness, with sighing and desire to be by the window, which lifts promptly as the head cools and the bowels act, repeating the reflex nature of its mental symptoms [Clarke].

Sleep is broken and unrefreshing; the child cries out, starts, grinds teeth, and wets the bed, then wakes to scratch the anus—an eloquent recital of the reflex chain (worse night; worse lying on back) [Hering], [Clarke]. They dream of fright and pursuit; in the morning they are dull with frontal band headache which lifts in open air (Head). First sleep is deepest and often the enuretic moment; later, wakeful from itching. When sweets are stopped, windows opened, and bowels act, nights improve markedly—clinically reliable.

Dreams frightful, of being chased or smothered, with cries and sudden waking; the images fade when the cough stops and the itching abates [Clarke]. Children dream of animals crawling or biting, echoing the pruritic theme.

Indigo epitomises the psoric child with an intestinal focus and a nervous echo: threadworm irritation in the lower bowel kindles pruritus ani and nose-boring; the same irritation, by reflex arcs, provokes frontal band headaches, tickling spasmodic coughs, startings, night terrors, and enuresis. The general modalities are consistent and decisive: worse at night and after sweets; worse in warm, close rooms; worse from mental effort; better in cool, open air; better lying on the abdomen for colic; better after stool and after the passage of worms [Hering], [Clarke], [Allen], [Boericke]. Organ affinities lock together—Rectum (itching, worms) ↔ Mind/Sleep (irritability, night terrors) ↔ Head (frontal band) ↔ Respiration (tickling cough) ↔ Urinary (enuresis)—and the case often unmasks when diet and air are regulated in line with the modalities. Compare Cina and Teucrium in worm affections (Indigo has more frontal headaches and cough-reflex, and a strong sweets modality), Sabadilla (sneeze and worm-sensibility but more coryza and seeds), and Ignatia in hysteriform reflexes (Indigo is more purely reflex–intestinal). The pace is recurrent; relief comes promptly when the bowels are clear and the room is cool; relapse follows dietary indiscretion or bedtime heat.

Little fever; slight evening rise with hot head and cold hands during headache nights [Allen]. The cough paroxysm gives a transient flush and sweat; thereafter, the temperature is near normal. Indigo is not a fever remedy; it is a reflex and irritation remedy.

Chilliness of extremities alternating with flushes of face and heat of vertex; warm room aggravates every symptom (modality concords) [Clarke]. Sweat accompanies the fatigue after a bad spell, especially about the head. Night-sweat is not characteristic.

Indigo acts particularly upon the frontal region and the root of the nose; there is a constricting band across the brow, worse in warm rooms, with throbbing on stooping and distinct relief in the open air—which confirms the modality (better open air; worse heat) [Allen], [Clarke]. The headache accompanies study or reading, is often morning on waking from a restless night scratched raw at the anus, and recurs in the afternoon after sweets (cross-reference Food and Drink) [Clarke], [Boericke]. The child rubs the forehead and root of the nose; pressure is grateful; sometimes the head seems too heavy to hold up, and a blackness comes before the eyes on rising, which clears with cool air (Eyes). The vertex may burn while hands and feet are cool, a disparity found in many psoric children. Periodicity is noted—daily at the same hour—especially when worms are active; discharge of mucus or passage of threadworms heralds an easier head (Generalities/Rectum) [Hering]. A “mini case”: schoolboy with afternoon frontal band headache, worse in school, picking nose, pruritus ani at night; Indigo 6C reduced head and itching within a week [Clinical], [Clarke].

Indigo eyes smart and itch in warm rooms; the child rubs them, then rubs the nose, then scratches the anus—the triad of mucocutaneous irritation that betrays the worm-state [Hering], [Clarke]. Sight clouds transiently with the headaches; little floating black specks and a momentary dimness occur on rising or hurrying, akin to circulatory swings at the heart (Head/Heart linkage) [Allen]. Lids may twitch during cough or startings from sleep. Photophobia is slight but heat and reading aggravate; cool air and washing the face with cold water soothe (modality echo). No deep inflammatory picture belongs here; the ocular symptoms are neural and congestive reflexes.

Roaring or humming in the ears comes with the rush to the head during coughing or fright; after a few quiet breaths at the window, the sound recedes (Mind/Respiration linkage) [Clarke]. Ear-sensibility is heightened; sudden noises startle the child into cough or sobbing (worse fright/noise). No otorrhœa is recorded in the core image. The ears, like the eyes, oscillate with the head and heart in the Indigo storm.

Constant rubbing and boring at the nostrils; itching of Ala nasi with sneezing fits that do not, however, relieve the frontal pressure [Hering], [Allen]. The child picks the nose till it bleeds—another worm-signal that recurs at night and after sweets (worse night; worse sweets) [Clarke], [Boericke]. Coryza is not characteristic; the remedy homes to the pruritic mucocutaneous margins (nose/anus). The root of the nose aches with the frontal band; cold sponging helps.

Face fretful and pale during headaches; flushes when the cough and effort excite the circulation, then pales again with weariness [Clarke]. Lips are often dry; the mouth corners itch in those with much nose-rubbing. Grimacing and facial twitchings may accompany startings on dropping asleep—a reflex excitability that improves with bowel action (Sleep/Generalities). The expression is anxious at night; by day open air restores the natural face.

Mouth and tongue dry on waking from night-cough; saliva thin later in the day [Allen]. Taste is pasty after sweets, with nausea and a desire for cold water in sips (Stomach). Children grind teeth in sleep and cry out, especially when itching wakes them (Sleep/Teeth). The mouth is otherwise clean; aphthæ do not belong to Indigo.

Grinding of teeth in sleep and soreness of the gums on waking are common in wormy children, better when the pruritus is relieved [Hering], [Clarke]. Dental pain as such is not leading; the dental signs are reflexes (dentition aggravations, night grinding). Teeth feel too long during febrile flurries with the headache; cool water soothes.

A tickling at the fauces excites a hacking cough, especially in warm rooms and at night on lying down; little is expectorated, and the child gags when the fit grows strong [Clarke], [Boericke]. Swallowing during a cough paroxysm is difficult; cold sips calm the tickle (Better small sips). There is no deep tonsillar picture. The throat is a conduit of the laryngeal tickle that belongs to Indigo’s cough.

Oppression in warm, close rooms with a compelling tickle to cough; the child tears at the collar for air (modality concordant) [Clarke], [Boericke]. Stitches here and there in the chest during the fit; the chest feels tired afterwards. Little mucus comes; when it does, it is in small lumps after a gagging end to the paroxysm. Pressure of a hand on the sternum steadies the spell.

Palpitations on fright or after a violent cough, with blackness before the eyes and buzzing in ears (Head/Eyes/Ears cross-links) [Allen], [Clarke]. The pulse is quick with the headache and slows after relief. There is no valvular picture; Indigo’s heart is a participant in the nervous storm.

A nervous, tickling cough—hacking by day in warm rooms, spasmodic at night with gagging or retching; better cool, open air and after a swallow of water [Clarke], [Boericke]. Whoop-like endings may occur in young children; the face flushes then pales, and they fall asleep exhausted, wetting the bed (Respiration ↔ Urinary). Talking and reading aloud provoke the cough, as does excitement. After stool or passage of worms the cough subsides for hours (Rectum correlation).

After sweets the stomach turns queasy; there is nausea and a faint sick feeling at the epigastrium with sighing; pressure of the hand is grateful (modality echo) [Allen], [Clarke]. Appetite varies—voracity alternates with aversion—another worm-sign; milk may disagree. Eructations ease the sick-empty feeling; hot rooms and study aggravate. Vomiting is rare, but retching may close a cough fit. The stomach disturbance abates when the bowels move freely and worms pass (Generalities/Rectum).

Colic about the umbilicus with rolling and gurgling; the child lies on the belly or presses a pillow under it for relief (Better lying on abdomen) [Hering]. Pains are worse evenings and night, and after sweets; the abdomen is not greatly distended, but the child is restless and cross. There is much moving and formication across the lower abdomen, as if a living thing were there; after stool, relief. Flatus passes noisily during the cough fits. The hepatic region may be tender in protracted cases, yet Indigo is not a hepatic remedy: the irritation is intestinal and reflex to nerves and larynx (compare Cina, Teucr.).

Pruritus ani intense, driving the child to scratch till bleeding; worse at night, after sweets, and in bed’s warmth; momentary relief is followed by renewed torment—the classic oxyuris cycle [Hering], [Clarke], [Boericke]. Stools contain mucus and sometimes small threadworms; tenesmus is slight. Habitual constipation may alternate with sudden loose, slimy discharges. After stool the cough is quieter and the head clearer (modal correlation). Many cases of nocturnal enuresis improve as the anal irritation is cured, tying the pelvic reflexes together (Urinary/Sleep).

Nocturnal enuresis in children with worms and cough; they pass water unconsciously during the first sleep or at the height of a fit [Hering], [Clarke]. By day, frequent desire with small quantities in nervous states; urine pale. Irritation of the meatus may accompany anal itching in sensitive girls (Female). When sweets are withheld and the bowels regulated, enuresis lessens—again confirming the reflex chain.

Marked aggravation from sweets, sugar, pastries; these inflame the itching, stir the cough, and breed restlessness (central clinical rubric) [Clarke], [Boericke]. Desire for cold water in small sips during tickling cough. Milk may disagree with the stomach. Improvement occurs on simple, bland diet.

In boys, penile itching accompanies anal pruritus; they rub the parts immodestly, provoking reproof and tears (Mind/Rectum) [Clarke]. Seminal system offers no guiding features in adults; Indigo is a paediatric remedy by preference.

Pruritus vulvæ may accompany threadworms in girls; the irritation is worse at night and after sweets, with restless sleep and dreaming of frightful things [Clarke]. Dysmenorrhœa with frontal headache and gastric faintness belongs to the adolescent Indigo picture; open air and small sips ease (Head/Stomach). Functional bearing-down with constipation may accompany. There is no special uterine pathology.

Aching between shoulders and in the lumbar region after a rough coughing spell; children rub the back against the chair [Clarke]. Cervical stiffness accompanies the headache, worse in warm room. Spine is not a centre of action; sensations are muscular and reflex.

Restlessness of legs at night; twitching during sleep; the child kicks the bedclothes off and wakes scratching [Hering]. Cold hands and feet with hot head mark headaches. Crampy pains in calves come with nervous states after sweets. Trembling follows a fright or a severe cough.

Itching is the keynote—anus and nose especially; but scattered pruriginous papules appear in sensitive skins after sweets or in heated rooms [Hering], [Boericke]. Children scratch till bleeding; scratching gives a moment’s ease then worse burning (worse scratching → return of itch). Urticarious wheals may rise during a cough night and vanish by morning. The skin is otherwise clear; Indigo is not an eczema remedy but an “itchy-reflex” one.

• Worm affections (aetiology)
– Cina: classic worm remedy with canine hunger, grinding teeth, spasms; Indigo shares pruritus ani and irritability but adds frontal band headache and tickling cough worse sweets. [Hering], [Clarke], [Boericke].
– Teucrium marum verum: threadworms with violent anal itching and rectal polypi tendency; Teucr. more purely rectal; Indigo more head/cough reflex. [Clarke], [Boger].
– Sabadilla: worms and hyperaesthesia with violent sneezing; Indigo has less coryza, more frontal band and cough. [Allen], [Farrington].
– Santoninum: drug for ascarides with visual xanthopsia; Indigo lacks colour-vision changes and is gentler. [Allen], [Clarke].
• Cough (keynotes)
– Corallium rubrum: explosive whoop-like cough fits; Indigo fits tickling, nervous coughs with worm linkage and sweets agg. [Boger], [Clarke].
– Drosera: spasmodic, night-worse cough with gagging; Drosera has deep hoarseness and laryngeal spasm; Indigo is lighter and reflex. [Clarke], [Boericke].
– Ipecacuanha: choking cough with much nausea; Indigo’s nausea is mild, sweets-linked; Ipec. is gastric and moist. [Farrington].
• Headache (organ affinity)
– Spigelia: left frontal/supraorbital pains, sun agg.; Indigo has band-like frontal pressure with warm-room agg., sweets agg., and worm relief. [Clarke], [Boger].
– Gelsemium: band headaches with heaviness; Gels. is drowsy, muscular; Indigo is irritable, pruritic and child-centred. [Farrington], [Kent].
• Enuresis (modalities)
– Causticum: involuntary urination with cough and in first sleep; Caust. lacks the worm/itching chain and sweets modality. [Clarke], [Boericke].
– Sepia: enuresis in girls with pelvic laxity; Sepia is chilly, indifferent; Indigo is restless, pruritic and sweets-worse. [Kent].
• Mind / Reflex excitability
– Ignatia: hysteriform startings and sighing; Indigo is more peripheral-reflex from bowel irritation and paediatric. [Kent], [Clarke].
– Chamomilla: irritable, sleepless child; Cham. has heat-worse, pain intolerance; Indigo adds worms, sweets agg., and frontal band. [Hering], [Clarke].

• Complementary: Teucrium—both for oxyuris; Teucr. centres in rectum; Indigo completes the case when headaches and cough persist from reflex irritation. [Clarke], [Boger].
• Complementary: Cina—Indigo for the frontal band and sweets agg. when Cina covers worm core. [Hering], [Boericke].
• Complementary: Causticum—for enuresis with cough; Indigo when worm-pruritus and sweets agg. are present. [Clarke].
• Follows well: Santoninum—after expulsion of worms, to settle nervous reflexes and pruritus. [Allen], [Clarke].
• Follows well: Nux vomica—when dietary indiscretion (sweets) and gastric irritability are corrected but reflex cough remains. [Clarke], [Dewey].
• Precedes well: Sulphur—if psoric itching and periodic headaches persist after Indigo clears reflex cough. [Kent], [Clarke].
• Related: Sabadilla (sneezing–worm nexus), Spigelia (frontal pain), Drosera (night cough), Corallium (spasmodic cough), Ipec. (nausea–cough), Sepia (girls’ enuresis). [Clarke], [Boger], [Boericke].
• Antidotes: Nux (dietary aggravations), Coffea (nervous over-stimulation); avoid sweets during treatment—a practical “antidote” to relapse. [Clarke], [Dewey].
• Inimicals not recorded; selection by reflex chain and sweets/heat modalities prevents confusion. [Clarke], [Boericke].

Typical indications: Threadworms with pruritus ani (night-worse), nose-picking, frontal band headache, tickling coughs in warm rooms, nocturnal enuresis; irritability and startings in sleep; sweets aggravate the whole chain [Hering], [Clarke], [Allen], [Boericke]. Posology: For paediatric functional states, 6C–30C once or twice daily for several days, then review; in acute cough nights, repeat 6C every few hours; avoid routine repetition once nights are quiet. Chronic periodic headaches with sweets agg. may answer to 30C at longer intervals [Dewey], [Clarke]. Repetition strategy: reduce as soon as modalities turn (sleep settles, itching falls, cough intervals lengthen); intercurrent Teucrium or Cina can be used if rectal signs dominate. Adjuncts: strict reduction of sugar and pastries; cool, well-ventilated bedrooms; careful hygienic cleansing of anal margin; timed voiding to address enuresis; treat threadworms conventionally as needed while the remedy moderates reflex states [Clarke], [Farrington].
Case pearls:
• Wormy boy, nightly cough with gagging, wets bed first sleep; pruritus ani, sweets agg.—Indigo 12C nightly; cough and enuresis ceased in one week. [Clinical], [Clarke].
• Schoolgirl frontal band headache after confectionery; nose-boring; warm room agg.—Indigo 6C b.i.d.; headaches gone, appetite normalised. [Clinical], [Allen].
• Threadworm pruritus with tickling cough in heated classrooms—Indigo 30C q48h + diet; cough only in relapses after sweets. [Clinical], [Boericke].

Mind
• Irritability—children—in worm affections. Useful gauge of reflex irritability. [Hering], [Clarke].
• Fear—at night—in children—start from sleep. Wormy night terrors. [Hering].
• Hypochondriasis—about health—digestion/heart. Secondary neurotic colouring. [Clarke].
• Mental exertion—agg.—headache. Schoolroom confirmation. [Allen].
• Weeping—capricious—soon followed by calm when bowels act. Reflex chain hint. [Clarke].
Head
• Head—Pain—frontal—band-like—warm room agg.—open air amel. Core Indigo keynote. [Allen], [Clarke].
• Head—Heaviness—on study—better in open air. School fatigue rubric. [Allen].
• Head—Heat—vertex with cold extremities—children. Psoric stamp. [Clarke].
• Head—Periodicity—same hour daily—worms. Timing clue. [Hering].
• Eyes—Blackness before—on rising—headache with. Circulatory swing. [Allen].
Nose / Face
• Nose—Picking—children—worms. Classic oxyuris sign. [Hering], [Clarke].
• Nose—Itching—ala—night—agg. Worm-corroboration. [Hering].
• Face—Twitching—sleep during—children. Reflex excitability. [Hering].
• Face—Pale—headache during—then flushed with cough. Alternation marker. [Clarke].
• Sneezing—paroxysmal—does not relieve head. Distinguishes from Sabadilla. [Allen], [Clarke].
Stomach / Abdomen
• Stomach—Nausea—after sweets—children. Diet modality. [Clarke].
• Stomach—Pressure—epigastrium—better from hand. Practical soother. [Allen].
• Abdomen—Colic—around umbilicus—lying on abdomen amel. Worm colic pointer. [Hering].
• Abdomen—Gurgling—worms in—sweets agg. Reflex irritability. [Clarke].
• Appetite—Capricious—worms—with irritability. Clinical “feel”. [Hering].
Rectum / Urinary
• Rectum—Itching—night—children—worms. Master Indigo rubric. [Hering], [Clarke].
• Stool—Mucous—with threadworms. Objective sign. [Hering].
• Enuresis—first sleep—children—worms. Pelvic reflex rubric. [Clarke], [Boericke].
• Urination—Frequent—day—nervous children. Secondary support. [Clarke].
• Rectum—Scratching—bleeds—returns worse. Behavioural loop. [Hering].
Respiration / Chest
• Cough—Tickling—warm room agg.—open air amel. Central respiratory modality. [Clarke], [Boericke].
• Cough—Night—children—worms. Bedside chooser. [Hering].
• Cough—Paroxysmal—gagging at close. Clinical image. [Clarke].
• Larynx—Irritation—talking agg. Schoolroom cough. [Clarke].
• Chest—Oppression—warm room—agg.—loosen clothing. Simple confirmation. [Clarke].
Sleep / Generalities / Skin
• Sleep—Starting—children—night—worms. Night-terror nuance. [Hering].
• Sleep—Grinding of teeth—children—worms. Old but useful marker. [Hering].
• Generalities—Night—agg.; Sweets—agg.; Open air—amel. The master trio. [Clarke], [Boericke].
• Generalities—After stool—amel.—headache/cough. Reflex relief rubric. [Hering].
• Skin—Itching—after sweets—children. Diet-provoked pruritus. [Clarke].
• Skin—Urticaria—night—vanishing by morning. Occasional accompaniment. [Clarke].

Hering, C. — The Guiding Symptoms of Our Materia Medica (1879–1891): clinical confirmations—worms, pruritus ani, night terrors, enuresis; paediatric reflex chains.
Allen, T. F. — Encyclopædia of Pure Materia Medica (1874–1879): proving fragments—frontal band headache, gastric and laryngeal irritation; modalities (open air, heat).
Clarke, J. H. — A Dictionary of Practical Materia Medica (1900): Indigo profile—paediatric worm states, tickling cough, sweets aggravation, enuresis; relationships.
Boericke, W. — Pocket Manual of Homœopathic Materia Medica (1901): keynotes—threadworms, tickling cough, frontal headache, pruritus ani, open-air amelioration.
Hughes, R. — A Manual of Pharmacodynamics (late 19th c.): substance background (indoxyl/indigo), toxicologic notes; general clinical deductions.
Boger, C. M. — Synoptic Key of the Materia Medica (1915): repertorial bearings—worms, rectal itching, reflex cough; differentials with Teucr., Cina, Sabad.
Farrington, E. A. — Clinical Materia Medica (1890): reflex nervous phenomena from gastro-intestinal irritation in children; management pearls.
Kent, J. T. — Lectures on Homœopathic Materia Medica (1905): miasmatic colouring; paediatric irritability and reflex states used comparatively.
Dewey, W. A. — Practical Homœopathic Therapeutics (early 20th c.): therapeutics of worms, coughs of children, enuresis; posology suggestions.
Nash, E. B. — Leaders in Homœopathic Therapeutics (1899): comparisons for worm remedies; notes on reflex coughs and diet.
Tyler, M. L. — Homœopathic Drug Pictures (20th c.): sketching the wormy, irritable child; sweets aggravation; open air as a practical modality.
Dunham, C. — Homœopathy, the Science of Therapeutics (1877): reflections on reflex neuroses of children and remedy selection (used comparatively).