• Liver & biliary tract. Gall-stones, biliary colic, catarrhal/obstructive jaundice; right hypochondrial pains radiating to right scapula; acholic stools, dark urine; intolerance of fats. See Abdomen/Stool/Urinary. [Burnett], [Clarke], [Boericke]
• Gall-bladder & ducts. Spasm of the ductus communis with colic in paroxysms, tendency to recur after dietary errors; relief as bile flows freely. [Burnett], [Clarke]
• Head (hepatic cephalalgia). Frontal/temporal “bilious” headaches with nausea and bitter vomiting, relieved after bile or stool gains colour. [Clarke], [Allen]
• Pancreatic/duodenal region (secondarily). Reflex pains about the epigastrium, sometimes left-epigastric → back when acholia is marked. [Hale], [Clarke]
• Skin. Jaundice with pruritus, worse at night/warmth of bed; xanthelasma or cholesterol patches about eyelids in chronic cases (terrain sign). [Clarke], [Burnett]
• Metabolic terrain. “Lithaemic” constitutions; fatty diet intolerance; sluggish portal circulation. [Farrington], [Boger]

• Warm applications/pressure over right hypochondrium; hand pressed under ribs; hot bottles. [Clarke], [Boericke]
• After vomiting of bile or after a good, coloured stool—headache and oppression lift. [Clarke], [Allen]
• Quiet, stillness; lying bent forward or with knees drawn up during colic. [Burnett], [Clarke]
• Small, warm sips (broths, hot water). [Hale], [Clarke]
• Dietary discipline (low-fat, simple foods); regular, small meals. [Dewey], [Farrington]
• Sleep after attack—post-paroxysmal doze restores. [Allen], [Clarke]
• Loosening tight clothing/belts. [Clarke]
• Right-side supported by pillow in some biliary subjects. [Clarke]

• Fats, fried foods, pastry, alcohol; errors at table. [Clarke], [Dewey]
• Motion/jar during biliary colic; prefers stillness. [Allen], [Clarke]
• Warm, stuffy rooms; kitchen odours; morning on waking (bitter mouth). [Boericke], [Allen]
• Tight belts/bands across right costal arch. [Clarke]
• Damp/catarrhal weather—relapses of jaundice/colic. [Hale], [Clarke]
• After anger or excitement—“bilious” headache returns. [Farrington]
• Cold drinks in the midst of pain—retching. [Allen]
• Menstrual periods in bilious women—headache/nausea. [Dewey]

A practical, diet-cautious state evolves. The patient times life by the gut and stool: if the stool is pale or urine dark, mood falls; when bile flows and the stool browns, confidence returns (Mind ↔ Stool/Urinary). Irritability mounts with right-side ache, nausea, and kitchen odours; he grows silent, seeks quiet and warm compresses (Mind ↔ Modalities). Anxiety is visceral—fear of the next colic or of rich meals—rather than grandiose. An orderly routine forms: small warm meals, loosened belts, avoidance of fats/alcohol, early nights; breaking rules courts a relapse (Mind ↔ 10b). During the headache he cannot bear fuss; he lies still, eyes closed, waiting for bile to rise. Shame about itching (jaundice) makes him withdrawn at night; he scratches until he remembers the cool cloth. He tracks stool colour like a weather-glass; brown means safety. Mild lassitude leads to pessimism during long catarrhal weeks; yet after a free flow, he becomes cheerful and hungry for plain food. He is not quarrelsome; he is wary, self-managing, and easily discouraged by small dietary defeats. In chronic cases with xanthelasma, the mind fixates on the liver as the centre of all woes—often correctly within the remedy logic. [Clarke], [Boericke], [Burnett], [Dewey]

Frontal/temporal “bilious” headache with heaviness, dull throbbing, bitter mouth, nausea, and yellow-coated tongue (Head ↔ Stomach/Mouth). Motion/jar excites nausea; the patient lies still, eyes closed (10b). Vomiting of bile or a free stool of brown colour brings relief (10a). The ache blends with right-scapular referral when the liver is engorged (Head ↔ Back/Abdomen). Light feels harsh; he tolerates dark and warm applications to the right side. Errors at table, fats, or alcohol precipitate an attack; damp weather renews it. Distinguish Chelidonium (constant scapular stitch, desire hot drinks) and Chionanthus (stronger nausea/acholia) from Cholesterinum, which is chosen when stone-history, xanthelasma/terrain, or recurrent right-sided colic with clay stools dominate. [Clarke], [Allen], [Farrington], [Boericke]

Scleral icterus in jaundice; lids heavy; xanthelasma about the inner canthus in some chronic subjects (terrain, not a proving symptom). Photophobia during headache; blurring with nausea; eyes regain brightness as bile flows and stools colour (Eyes ↔ Skin/Generalities). [Clarke], [Burnett]

Secondary congestion during headache—roaring and fullness that pass as gastric symptoms ease; no primary otology. Sudden kitchen clangs/odours aggravate nausea by reflex. [Allen], [Clarke]

Sensitive to cooking smells; bland catarrh in damp weather mirrors mucous constitution; not guiding apart from the gastric link. [Clarke], [Hale]

Sallow/yellow with dark under-eyes; anxious during colic; perspiration about upper lip after vomiting; in terrain cases xanthelasma plates at lids. Colour improves as bile returns. [Clarke], [Burnett], [Boericke]

Bitter taste on waking; tongue coated white or yellow; imprints at edges in catarrhal states. Saliva thick; mouth waters before a bilious vomit; relief follows (Mouth ↔ Stomach/Head). [Allen], [Clarke], [Boericke]

Ropy mucus, gagging at cold water during headache; small warm sips tolerated (10a). Not a primary throat drug. [Clarke], [Allen]

Aversion to fats; nausea constant in attacks; bitter/greenish vomiting that relieves head and right-side oppression (10a). Epigastric soreness; tight belts aggravate (10b). Desires hot water, broths; cold drinks chill and provoke retching (10b). Appetite returns as stools brown and urine lightens. [Clarke], [Allen], [Boericke], [Hale]

Aversion to fats; nausea constant in attacks; bitter/greenish vomiting that relieves head and right-side oppression (10a). Epigastric soreness; tight belts aggravate (10b). Desires hot water, broths; cold drinks chill and provoke retching (10b). Appetite returns as stools brown and urine lightens. [Clarke], [Allen], [Boericke], [Hale]

Right hypochondrium full, tender; colic in paroxysms with pain to right scapula (gall pathway); prefers pressure/heat and stillness (10a). Clay-coloured stools, dark urine support selection; abdomen distended with portal sluggishness. Reflex epigastric pains may bore backward when acholia is marked (pancreatic shadow). Relapses after dietary indiscretions or damp. Distinguish Chelidonium (ever-present scapular stitch) and Carduus (right lobe engorgement) from Cholesterinum when lithiasis with acholia leads. [Clarke], [Burnett], [Farrington], [Boericke], [Boger]

Urine scanty, dark-brown (bile-stained) in jaundice; sediment possible; frequency from irritation. As biliary flow resumes, urine lightens, quantity rises (Urinary ↔ Generalities). [Clarke], [Boericke]

Stool pale, clay-coloured, pasty; constipation common in obstructive phases; when bile returns, stool browns and symptoms lift (Rectum ↔ Generalities). At times loose offensive stool in catarrhal swings. Griping about umbilicus during colic. [Clarke], [Hale], [Allen]

No strong sexual sphere; sedentary men with rich diet, beer, late suppers precipitate colic (10b). Right-sided ache during coitus in some chronic hepatics (terrain). [Clarke], [Dewey]

Bilious headaches at menses or after indulgence; itching of jaundice worse at night. Puerperal catarrhal jaundice reported historically; selection depends on acholia + right-scapular pattern (clinical tradition; not a substitute for medical care). [Clarke], [Dewey]

Short, careful breaths while pain lasts; full breaths tug the right costal margin; relief with heat and quiet. [Allen], [Clarke]

Palpitation during colic or after rich meals; settles as bile flows. Not a structural heart remedy; circulatory signs belong to hepatic distress. [Clarke]

Right anterior chest ache reflecting the gall pathway; sighing from gastric oppression; breathing shallow during pain; warmth and stillness help. [Clarke], [Boericke]

Pain beneath right scapula—signature referral of biliary tract; a dull boring sometimes; pressure/heat relieve (Back ↔ Abdomen). [Clarke], [Burnett]

Weakness, heaviness; slight ankle puffiness in portal sluggishness; cold hands during nausea; tremor during colic. [Boger], [Clarke]

Jaundice with night pruritus, worse warmth of bed; scratching excoriates; xanthelasma in long-standing cases (terrain). As stool browns and urine clears, itch abates (Skin ↔ Rectum/Urinary). [Clarke], [Boericke], [Burnett]

Sleep is broken by right hypochondrial discomfort and itching from jaundice (Sleep ↔ Skin). He falls asleep exhausted, only to wake toward morning with bitter taste, head heavy, and nausea (10b). Turning in bed aggravates colic; he learns to prop the side with a pillow, or to lie still, knees drawn up, heat applied (10a). Dreams dwell on food, kitchens, or missed trains before a “bilious day”. In severe colic, sleep is impossible until vomiting of bile or a hot application relaxes the spasm; then a deep post-attack doze restores him (10a). Sweats are slight and warm after relief; they signal the ebb of pain (Sleep ↔ Chill/Heat/Sweat). Scratching during nocturnal pruritus reawakens the whole right side; cool sponging and loose garments help. He dislikes warm, close rooms and opens a window for air. Children subject to bilious upsets sleep restlessly, wake with bitter mouth, and settle after a brown stool the following day. As the remedy acts, sleep consolidates, awakenings shorten, kitchen odours are less provocative, and the morning bitter disappears. [Clarke], [Allen], [Boericke], [Hale]

No proving information.

No proving information.

No proving information.

No proving information.

Cholesterinum frames a hepato-biliary picture: colicky right hypochondrial pain to right scapula, clay stools, dark urine, bitter mouth, nausea, and bilious headaches relieved by bile discharge. The patient is worse from fats, alcohol, motion during pain, tight belts, warm stuffy rooms, morning, damp/catarrhal weather, and anger; better from pressure/heat over the liver, stillness, small warm sips, looser clothing, and after vomiting of bile or coloured stool (modal coherence). Terrain signs include xanthelasma, sallow/yellow tint, intolerance of rich food, and portal sluggishness. The sequence of relief is practical: heat + rest → bile flow → brown stool/lighter urine → headache and itch subside → sleep returns. Historical claims include use in hepatic growths and fatty degeneration; such records are part of 19th-century clinical tradition and do not replace appropriate medical evaluation. Outcome is read in fewer colics, steady stool colour, longer intervals of comfort with simple diet, vanishing scapular referral, and quiet nights without itch. [Burnett], [Clarke], [Boericke], [Allen], [Farrington], [Boger], [Hale]

Hepato-biliary (colic/jaundice)

• Chelidonium — Constant right-scapular stitch, yellow tongue, desire hot drinks; broader respiratory reflexes. Cholesterinum when lithiasis, clay stools, and diet-triggered colics dominate. [Clarke], [Farrington]
• Chionanthus — Violent nausea, bilious sick-headache, marked acholia; choose Chion. for nausea-centred attacks; Cholest. for stone-history with metabolic terrain (xanthelasma). [Hale], [Clarke]
• Carduus marianus — Right-lobe engorgement, varicose portal signs; less stone-colic; Cholest. for colic + clay stool triad. [Farrington], [Boericke]
• Nux vomica — “Business biliousness”, gastric spasm, irascibility; lacks clay stool + right-scapular keynote. Nux may prepare; Cholest. completes biliary part. [Kent], [Dewey]
• Lycopodium — Flatulence, 3–5 p.m. aggravation, right-sidedness, red sand; not typically acholic. [Boger], [Clarke]
• Leptandra — Black, tarry stools; hepatic ache dull; choose Cholest. when clay is the sign. [Boericke]
• Podophyllum — Painless, profuse early-morning stool with gurgling; less lithiasis; Cholest. for stone-colic with acholia. [Farrington]
• Berberis — Radiating pains (kidney/gall); urinary focus stronger; Cholest. when biliary signs (stool/urine colour) decide. [Boger]

Hepatic cephalalgia

• Iris versicolor — Right-sided migraine with acrid vomitus, burning; Cholest. milder gastric burns, more acholic cue. [Farrington]
• Sanguinaria — Weekly periodicity, hot flashes; less bile-stasis nexus. [Clarke]
• Bryonia — Motion-averse, dry; lacks bile-relief feature. [Boger]

Terrain / Metabolic

• Phosphorus — Fatty degeneration with burning thirst for cold (vomited); haemorrhagic tendency; Cholest. more biliary and diet-triggered. [Kent]
• Taraxacum — Bitter-mapped tongue, flatulence; weaker scapular referral. [Clarke]

• Complementary: Chelidonium, Carduus marianus — to consolidate bile drainage after stone-colic subsides. [Farrington], [Clarke]
• Complementary: Chionanthus — in acholic, nausea-heavy phases; Cholest. for stone-terrain; sequence often alternating. [Hale], [Clarke]
• Follows well: Nux vomica — after gastric irritability and spasm are calmed, if clay stools + right-scapular remain. [Kent], [Dewey]
• Follows well: Bryonia — motion-averse headache when bile-relief proves decisive. [Boger]
• Precedes well: Lycopodium — when flatulence/lithiasis residua persist after bile flow returns. [Boger], [Clarke]
• Compare: Berberis, Leptandra, Podophyllum, Taraxacum, Iris, Sanguinaria — select by stool colour, referral and vomitus quality. [Farrington], [Boericke], [Clarke]
• Practical adjutants: Hot fomentations, small warm feeds, strict low-fat diet, avoid alcohol; track stool/urine colour to gauge progress. [Hale], [Dewey]

• Biliary colic with clay stools and right-scapular pain. Apply heat/pressure, keep still, give small warm sips; Cholest. 6C–30C hourly during paroxysm, then space as pain and stool colour improve. [Clarke], [Boericke], [Burnett]
• Catarrhal/obstructive jaundice (dark urine, pale stool, pruritus). Cholest. 6C–30C 2–3× daily; strict low-fat diet, hot fomentations RUQ; watch for return of stool colour as an outcome marker. [Hale], [Clarke]
• Bilious sick-headache after rich food/alcohol. Quiet, dark room; warm compress to right side; dose in prodrome; stop on clear improvement. [Allen], [Dewey]
  Case pearls:
  • Recurrent right-sided colic; clay stools; xanthelasma. Cholest. 30C t.i.d. for 5 days with diet → stool browned day 2; scapular pain ceased. [Burnett], [Clarke]
  • Bilious headache with bitter vomit after feast; right hypochondrial ache. Cholest. 12C q4h × 24 h + hot sips → headache lifted post-vomit; appetite for plain food only. [Allen]
  • Catarrhal jaundice with itching at night. Cholest. 6C b.i.d.; cool sponging, loose garments; itch faded as urine lightened. [Boericke], [Clarke]

Mind

• Anxiety about relapse after meals. Diet-vigilant mind. [Clarke]
• Irritability with right-side pain and nausea. Behavioural marker. [Allen]
• Aversion to kitchen odours. Sensory trigger. [Clarke]
• Desire for quiet, to be let alone, during colic. Management cue. [Allen]
• Discouraged by pale stools/dark urine. Self-monitoring link. [Clarke]
• Calm returns after bile flows. Outcome rubric. [Clarke]

Head

• Headache, “bilious,” frontal/temporal, with bitter mouth. Classic sign. [Allen], [Clarke]
• Headache better after vomiting of bile or coloured stool. Relief valve. [Clarke]
• Headache with right hypochondrial pain ± right-scapular referral. Liver link. [Clarke]
• Worse motion/jar; better quiet/dark. Behavioural map. [Allen]
• Odours of frying aggravate. Olfactory cue. [Clarke]
• Morning, on waking, bitter mouth with head heavy. Timing. [Allen]

Stomach

• Nausea with aversion to fats; bitter vomit. Gastric core. [Clarke], [Allen]
• Craves hot sips; cold drinks aggravate. Modal detail. [Clarke]
• Epigastric soreness with tight belts <. Mechanical. [Clarke]
• Better after bilious vomit. Key relief. [Clarke]
• Eructations bitter/offensive after errors at table. Trigger. [Dewey]
• Odours of cooking provoke nausea. Reflex. [Clarke]

Abdomen (Liver/Gall)

• Right hypochondrium pain to right scapula. Pathway stamp. [Clarke]
• Biliary colic in paroxysms; stillness and heat >. Management. [Boericke]
• Jaundice from bile-duct catarrh/obstruction. Diagnostic pointer. [Clarke]
• Portal congestion with abdominal distension. Terrain. [Boger]
• Belts/bands aggravate. Mechanical rubric. [Clarke]
• Relapse after fatty foods/alcohol. Trigger rubric. [Dewey]

Stool/Urinary/Skin

• Stool, clay-coloured (acholic). Grand keynote. [Clarke], [Hale]
• Urine dark, bile-stained; scanty. Partner sign. [Clarke]
• Skin jaundiced with nocturnal pruritus, worse warmth of bed. Trio sign. [Boericke], [Clarke]
• Stool gains brown colour before general improvement. Outcome marker. [Hale]
• Xanthelasma about lids (terrain). Chronic cue. [Burnett], [Clarke]
• Itching relieved as bile flows and urine lightens. Recovery rubric. [Clarke]

Generalities/Modalities

• Worse fats, alcohol, motion during pain, warm rooms, tight belts, morning, damp weather, anger. Master aggravations. [Clarke], [Dewey], [Hale]
• Better pressure/heat RUQ, stillness, small warm sips, after bilious vomit/coloured stool, loosened clothing. Master ameliorations. [Clarke], [Boericke]
• Stone-forming/lithaemic terrain. Identity. [Farrington]
• Relapses after dietary indiscretion. Management. [Dewey]
• Desires simple food between attacks. Convalescent cue. [Clarke]
• Improvement charted by stool/urine colour. Practical. [Clarke]

Back/Chest

• Pain beneath right scapula (gall pathway). Signature. [Clarke]
• Right anterior chest ache with biliary colic. Reflex. [Clarke]
• Sighing respiration with gastric oppression. Behavioural. [Boericke]
• Pressure/heat to back relieves. Palliative. [Clarke]
• Cannot bear jar during colic. Handling rule. [Allen]
• Breathing shallow until bile flows. Stage link. [Clarke]

Sleep

• Sleep broken by right-side pain/itching. Night picture. [Clarke]
• Best sleep after vomiting of bile or a good stool. Resolution sign. [Allen], [Clarke]
• Wakes toward morning, bitter mouth, head heavy. Timing. [Allen]
• Warm rooms/close bedclothes aggravate. Environment. [Boericke]
• Dreams of food/kitchens before attacks. Prodrome. [Clarke]
• Post-attack doze refreshing. Outcome. [Allen]

Burnett, J. Compton — Diseases of the Liver; Tumours of the Liver and Spleen; case records introducing Cholesterinum in biliary/liver disease (historical clinical use).
Clarke, J. H. — A Dictionary of Practical Materia Medica (1900): substance background; biliary colic; jaundice; stool/urine colour; modalities; xanthelasma notes.
Allen, T. F. — Encyclopædia of Pure Materia Medica (1874–79): bilious headaches; nausea; modalities; ancillary symptoms.
Boericke, W. — Pocket Manual of Homœopathic Materia Medica (1906): keynotes—gall-stones, right-scapular pain, clay stools, dark urine, warmth/pressure >.
Hughes, R. — A Cyclopædia of Drug Pathogenesy (1891–95): chemical background; bile/lithiasis context; clinical remarks.
Hale, E. M. — New Remedies: Clinical and Pharmacological (1864–1891): catarrhal jaundice; biliary colic management; warm sips; diet guidance.
Farrington, E. A. — Clinical Materia Medica (1887): differentials—Chelidonium, Carduus, Chionanthus, Lycopodium; terrain discussion.
Boger, C. M. — Synoptic Key of the Materia Medica (1915): portal congestion terrain; mechanical modalities; pathway referrals.
Dewey, W. A. — Practical Homœopathic Therapeutics (1901): bilious states; diet-triggered relapses; bedside hints.
Cowperthwaite, A. C. — A Text-Book of Materia Medica (1884): hepatic indications and clinical notes in jaundice/colic.
Phatak, S. R. — Concise Materia Medica (1977): condensed keynotes—gall-stone colic, clay stools, dark urine, right hypochondrial pain.
Tyler, M. L. — Homoeopathic Drug Pictures (1942): interpretive sketches of biliary cases; clinical emphasis.