Cedron

Prepared from the seeds of Simaba cedron, a tropical American tree (New Granada/Colombia to Central America). The very hard, almond-like seeds contain intensely bitter quassinoids (quassin-type) and other bitter principles characteristic of Simaroubaceae. In folk medicine the seed was revered as a specific against the bites of venomous snakes and other poisonous creatures; it was also taken in fevers and agues. For homœopathic use, the dry seed is triturated and then tinctured/potentised. Pharmacologic and toxicologic notes emphasise intense bitterness, gastric stimulation, and a striking periodicity in provers’ pains and paroxysms, anticipating its clinical sphere in clock-like intermittent neuralgias and malarial periodicities ([Toxicology]/[Proving]) [Clarke], [Hale], [Hughes], [Allen].

Symptoms collected by Hering and others, with later clinical amplifications by Allen and Clarke. Hallmarks in the records include supra-orbital/trigeminal neuralgia with absolute periodicity (same hour daily or alternate days), malarial paroxysms with fixed times, and remarkable benefit in bites and stings ([Proving]/[Clinical]) [Hering], [Allen], [Clarke], [Hale].

Cedron is the chronometer of Materia Medica. Where others speak of “periodic,” Cedron sets a minute hand: the brow storm gathers and strikes at the same hour—sometimes the same minute—and then, with ritual obedience, passes through chill, heat, and sweat until the body is released. This sycotic periodicity eclipses personality; the patient orbits the clock, not his moods. Kingdom clues (Simaroubaceae bitters) give a quassia-like antiperiodic tone—sharp, penetrating, nervine—and a field history in tropical fevers and bites, mapping to Cedron’s clinical gravitas in marsh-weather neuralgias and venom-type pains ([Proving]/[Clinical]) [Hale], [Clarke], [Allen], [Hughes].

Psychologically he is ordered and anticipatory: the day is partitioned into safe and unsafe zones. As the hour nears, the world narrows—conversation shrinks, the brow is banded, light is shunned, wind avoided. When the paroxysm peaks, touch to the supra-orbital notch becomes impossible, yet earlier the same pressure may have postponed the storm—Cedron’s characteristic pre- vs mid-attack reversal. In contrast with Spigelia, which dramatises eye motion and heart echoes, Cedron’s intensity is temporal and meteorologic: storms, marsh mists, dawn/dusk hand the baton to the trigeminal nerve; after the sweat, the baton is laid down. Compared with China/Chin-s., Cedron is less about blood-loss and tympany and more about precise scheduling; compared with Nat-m., it prefers the minute to the month and the orbit to the heart.

Miasmatically, the pattern is sycotic recurrence on a fixed timetable, interleaved with psoric exhaustion after paroxysm; a thin syphilitic line appears in venom-like destructive stabs and vaso-neural spasm if neglected [Kent], [Sankaran]. The modalities are airtight and must echo across sections: worse at the exact hour, worse storms/damp heat, sunrise/sunset, wind on face, coffee/alcohol on the day; better between attacks, after sweat, with dark, heat, band-pressure (only before the attack), gentle motion in prodrome, and sleep immediately after. The clinical “end-points” are unambiguous: the hour shifts, intensity falls, the cycle breaks, and the patient forgets the clock—the essence of a Cedron cure.

• Trigeminal nerve (supra-orbital branch). Stabbing, burning, radiating neuralgia round the eye and brow with clock-like periodicity; pains sweep in a ring to temple/occiput; often left-sided but can alternate ([Proving]/[Clinical]) [Hering], [Allen], [Clarke]. See Head/Eyes/Face.
• Periodic fevers (malarial type). Chills/fevers recur at fixed hours or every second/third day; prodromes include orbital pain and aching bones; thirst modalities vary by stage ([Clinical]) [Hale], [Clarke]. See Fever/Chill/Generalities.
• Orbit & ciliary nerves. Neuralgic, congestive ophthalmia with pericorneal injection and photophobia following malaria; pains radiate from brow/inner canthus ([Clinical]) [Allen], [Clarke]. See Eyes.
• Occiput/temporal nerves. Head pains circle from brow to occiput like a band; tingling scalp during onset; recurs at the exact hour [Allen], [Hering]. See Head.
• Autonomic vaso-motor. Sudden flushes, chills, sweat in rigid sequence; skin cold during neuralgic stage; vasospastic traits [Hughes], [Allen]. See Chill/Heat/Sweat.
• Peripheral nerves (bites, stings). Venom-type pains, burning lines from the point of injury; reputed antidotal action in snake/scorpion lesions ([Clinical]/tradition) [Hale], [Clarke]. See Skin/Generalities.
• Spleen/liver (post-malarial). Congestion and left hypochondrial dragging after intermittents; less organ-fixed than Ceanothus/China but present in chronic ague subjects [Clarke], [Farrington]. See Abdomen/Generalities.
• Genital neuralgias. Ovarian/testicular pains with periodic return; paroxysmal, vaso-neural background ([Clinical]) [Clarke], [Allen]. See Female/Male.

The Cedron mind learns life by the clock. Confidence rises with long free intervals and collapses as the appointed hour approaches; the patient becomes watchful, counting minutes, a tense expectancy that itself precipitates the paroxysm (Mind ↔ 10b “anticipation worse”) [Clarke]. Irritability mingles with dread; the fear is not abstract but temporal—“it will come exactly at …”—a unique focus compared with China’s exhaustion or Arsenicum’s existential anxiety [Farrington], [Kent]. During the attack, the mind narrows to the orbit of pain: face pinched, speech brief, movements economical lest any jar ripple the trigeminal field (Mind ↔ Head/Eyes) [Allen]. Between attacks, there can be an agreeable lucidity and even briskness; the patient insists he is well if it is not the hour (Mind ↔ Better during interval) [Clarke]. The psyche is often meteorologic; knowledge that a storm is brewing or a muggy marsh-wind is blowing may darken the mood, prefiguring relapse (Mind ↔ Generalities/Modalities) [Hale]. Sleep becomes a bargaining chip—if he sleeps before the time, he hopes to skip the hour; if kept awake, he resigns himself to its exactness (Mind ↔ Sleep) [Allen]. Cedron is less theatrical than Spigelia; its mental signature is precision without panic, a stoic resignation tempered by small rituals (tight band, dark room, hot cloth) which, though insufficient at the hour, lend a sense of control [Farrington], [Clarke]. Post-malarial subjects display cautious planning: avoiding late meals, marsh paths, and long exposure at dawn/dusk (Mind ↔ Stomach/Respiration). After many cycles the mood may flatten into clock-bound melancholy, relieved as soon as the sweat completes the fever sequence (Mind ↔ Fever/Heat/Sweat) [Clarke]. The overall mental essence is that of the chronometric sufferer: ordered, anticipatory, weather-sensitive, and paradoxically well between storms.

Sleep is a tactical refuge but fragile near the hour; many wake a few minutes before the time, as if the organism kept vigil (Sleep ↔ Mind) [Allen]. Between attacks, sleep is refreshing; after nights of lost sleep the next day’s paroxysm intensifies (10b) [Allen]. Dreams may map the fear of the clock—missing a train, bells chiming the hour; consolidation returns once periodicity is broken (Sleep ↔ Generalities). Naps immediately after the sweat are profoundly restorative (10a) [Clarke]. A strict bedtime ritual is adopted to “get ahead” of the time signature; any disruption brings relapse.

Temporal symbols—clocks, exams at fixed times, sunsets—recur; being late or arriving at the hour marks the psyche’s imprint of periodicity (Dreams ↔ Mind) [Clarke]. Content fades as intervals lengthen.

The genius is time: pains and fevers recur by the clock—sometimes to the minute—and the patient is well between ([Proving]/[Clinical]) [Hering], [Clarke]. Weather-malarial milieus, storms, and marsh winds are treacherous; geography is a modality (worse tropics/swamps) [Hale]. The organism obeys a rigid sequence (neuralgia → chill → heat → sweat → relief); to break the spell is to cure (Generalities ↔ Fever). Sensory over-irritability is regional (orbit), motor economy global (stillness during hour). The remedy equals Spigelia in orbital intensity but surpasses all in chronometry; it equals China/Chin-s. in periodicity but narrows to trigeminal and meteorologic cues [Farrington], [Clarke]. Recovery shows as drift of the hour, softening of the ring-pain, shorter heat, and spontaneous sweat with post-attack sleep.

A classic intermittent: chill → heat → sweat in orderly file, recurs at the same hour; often clock-regular daily or tertian/quartan ([Clinical]) [Hale], [Clarke]. Chill begins with supra-orbital pain; heat with dry, burning skin and throbbing temples; sweat copious, relieving neuralgia and restlessness (Fever ↔ Head/Generalities) [Clarke], [Allen]. Thirst patterns vary; many crave cold water before chill, little during heat, and again before sweat (stage-specific) [Allen]. Distinguish China/Chin-s. (periodicity but more gastric/flatulent and sound-sensitive), Nat-m. (sun-linked, lip herpes, grief), Eupatorium (bone-breaking) [Farrington], [Clarke].

Chill sharp, hands/feet icy; orbital pain at apex; shivering at minute-marked onset (Chill ↔ Head) [Allen]. Heat with flushed face, burning eyes, throbbing temples; touch to brow intolerable (Heat ↔ Eyes/Head) [Clarke]. Sweat profuse, warm, with a felt letting-go of pain; failing to sweat prolongs agony (10b Worse suppressed sweat) [Clarke].

Supra-orbital neuralgia is the flagship complaint: stabbing, boring, burning pains centred at the supra-orbital notch, radiating round the eye to temple and occiput in a ring (Proving) [Allen], [Hering]. The pains are periodic to exactness—striking at the same hour daily or every second/third day—and may be heralded by tingling scalp or a minute thread of pain that swells to a band [Clarke], [Allen]. Side-affinity is often left though alternation occurs; motion, light, wind, and jarring footsteps intensify the bolt (10b) [Allen]. Pre-pressure at the notch may delay onset, yet during the attack the slightest touch is intolerable—an instructive reversal (10a/10b nuance) [Allen]. Comparatively, Spigelia is left-orbital with marked eye-movement aggravation and cardiac echoes; Cedron is defined less by heart and more by time, weather, and marsh exposure [Farrington]. China/Chininum sulph. share periodicity but lack the supra-orbital ring-pain signature; their headaches are more diffuse and gastro-vascular [Farrington], [Clarke]. As the fever cycle proceeds, the head pain may give way to heat and then to sweat, closing the loop (Head ↔ Fever) [Clarke].

Photophobia and ciliary neuralgia accompany the brow pains; the eye may water with pericorneal injection, lids twitch, and vision blur at the height of the paroxysm (Proving/Clinical) [Allen], [Clarke]. The globe feels too large, as if pressed from behind when the occipital arc is involved; rolling the eye is torture (Eyes ↔ Head) [Allen]. Light changes at sunrise/sunset trigger attacks, another periodic cue; a darkened room is gratefully sought (10a) [Allen]. After malaria there may be lingering malarial ophthalmia with noon or evening exacerbations; Cedron suits when the timings are exact and brow radiation defines the map [Clarke], [Farrington]. Distinguish Spigelia (knife through eye to occiput, worse eye movement, better closing eyes) from Cedron where time and weather outrank pure motion sensitivity [Farrington].

Little primary otology; yet a rhythmic roaring or rushing may begin as the hour draws near, a vascular accompaniment to the brow storm (Ears ↔ Head) [Allen]. Wind on the ear in damp heat precipitates the orbital stitch (Modalities). After the sweat, noises fall to silence (Fever/Heat/Sweat) [Clarke].

Tears and thin coryza may drip reflexly during the neuralgic surge; sneezing jars the orbit and intensifies the band-headache (Nose ↔ Head) [Allen]. Not a nasal remedy in its own right.

Pale or flushed by turns; the infra-orbital region may burn; face drawn on the painful side (Face ↔ Head) [Allen]. Tic-like twitches sometimes accompany the supra-orbital storm; touching the eyebrow is dangerous during the attack though tolerated between hours (10a/10b paradox) [Allen], [Hering].

Bitter taste (quassia family echo) is noted in some provers; saliva sour during fever stage (Proving) [Allen], [Hughes]. Teeth may ache sympathetically along the maxillary branch in periodic fashion; chewing is avoided at the hour (Mouth ↔ Face) [Allen].

Radiating neuralgia may seize upper incisors/canines in cadence with the supra-orbital pain; cold air on teeth during the hour aggravates (Teeth ↔ Head) [Allen]. Unlike Spigelia, toothache is subsidiary and temporal precision is diagnostic [Farrington].

Dryness during chill; swallowing jars the orbital zone at the height of pain (Throat ↔ Head) [Allen]. No constant inflammation.

Tightness just before chill with sighing; stitching below left breast that keeps time with the brow throbs (Chest ↔ Head/Fever) [Allen]. Cough jars the orbit during the hour.

Palpitation at onset of the paroxysm; pulse full or small depending on stage; resolves when sweat completes the cycle (Heart ↔ Fever) [Clarke]. Not a structural heart remedy—temporal reactivity rules.

Short, quick breaths during the rise of pain; deep inspiration may shoot the ring-pain backwards (Respiration ↔ Head) [Allen]. After the sweat, respiration lengthens and quiets.

Appetite is capricious; the patient fears eating near the hour lest gastric distension intensify vascular throbbing (10b After eating on attack days) [Allen]. Bitter eructations and nausea precede some fevers; small warm meals before the time are best (10a) [Clarke]. China’s tympany and desire for sour differ from Cedron’s chronometric gastric disturbance [Farrington].

Spleen/liver may feel heavy after seasons of ague—dragging left hypochondrium and fulness under right ribs in lesser degree (Abdomen ↔ Affinity) [Clarke]. Bowel function often pares down to once daily; loose stool can occur at fixed hours in some, mirroring the neuralgic timetable (periodic diarrhœa) [Allen]. As intermittent fevers resolve, abdominal weight recedes. Distinguish Ceanothus (organ-fixed spleen, positional ban) from Cedron (time-fixed paroxysm) [Farrington], [Clarke].

Occasional diarrhœa at a set hour, especially dawn or late afternoon; stool relieves head pressure in some (Rectum ↔ Head) [Allen]. Not a haemorrhoidal picture.

Urine scant during chill/heat; increases as sweat breaks (cyclic) [Clarke]. No specific renal pathology is central to selection.

Aversion to eating near the hour; coffee/alcohol aggravate on attack days; warm light meals earlier help (10a/10b) [Allen]. Desire for cold water just as chill begins; less thirst mid-heat [Allen], [Clarke].

Periodic testicular neuralgia or “cord pains” occurring at exact times; co-exists with supra-orbital schedule (Clinical) [Clarke]. Sexual desire indifferent; performance worsens if timing coincides with attack hours.

Ovarian pains (left > right) in bracelet-like paroxysms by the clock; catamenial aggravation at an exact daily hour; supra-orbital pain precedes menses on two or three days, then ceases (Female ↔ Head/Generalities) [Clarke], [Allen]. Differentiate Lachesis (left ovary, loquacity, after-sleep worse) by absence of rigid time signature in Lach. [Farrington].

Occipital radiation is frequent; pain feels as though a band encircled the nape at the appointed hour (Back ↔ Head) [Allen]. Damp winds across the neck are forewarnings (Modalities).

Cold hands/feet during chill; tremor sets in just before the attack, then eases as heat mounts (Extremities ↔ Chill/Heat) [Allen], [Clarke]. Neuralgic streaks may shoot down the arm on the painful side in rhythmic bursts.

Cold, goose-flesh during chill; prickling flush in heat; profuse sweat closes sequence (Skin ↔ Fever) [Clarke]. Bites/stings ignite burning tracks; Cedron has clinical repute for poison-bites, especially in the tropics (tradition) [Hale], [Clarke].

Periodicity (Intermittents)

• China (Cinchona) — Antiperiodic with gastric tympany, sound/light sensitivity after loss of fluids; lacks Cedron’s supra-orbital ring pain and clock exactness. Use China when weakness and flatulence dominate, Cedron when time and orbit lead. [Farrington], [Clarke]
• Chininum sulphuricum — Strong cyclicity (quotidian/tertian), tinnitus, throbbing; less topographical facial focus; Cedron when pain posts a minute hand. [Hale], [Allen]
• Natrum muriaticum — Sun-periodicity, vesicles on lips, grief aetiology; splenic enlargement common; Cedron has harder chronometry and supra-orbital neuralgia. [Farrington], [Clarke]
• Eupatorium perfoliatum — Bone-breaking aches, thirst before chill; orbital focus weaker; Cedron leads if head circlet pain rules. [Farrington]

Orbital/Trigeminal Neuralgia

• Spigelia — Left-eye stabbing, worse eye motion; cardiac palpitation often coexists; time less exact; choose Cedron if the hour is law. [Farrington], [Kent]
• Belladonna — Congestive, throbbing, flushed, high heat; not minute-exact; photophobia overlaps but storm-red features prevail. [Kent], [Clarke]
• Sanguinaria — Right-sided, periodic (every 7th day), circumscribed to hemicrania; gastric warmth helps; Cedron if hourly precision and marsh triggers dominate. [Clarke]

Bites and Stings / Vaso-Neural

• Lachesis — Venomous left-sidedness, talkative, worse after sleep; less clock-bound; Lach. for congestive, purple, haemorrhagic themes; Cedron for neural-clock and tropical bite legends. [Clarke], [Farrington]
• Crotalus — Haemorrhagic sepsis; systemic venom themes; Cedron is not septic but neural-periodic. [Kent]
• Ledum — Puncture wounds; coldness; not periodic by the clock. Cedron when stings/bites wake timed neuralgias. [Clarke]

Meteorologic / Geographic

• Rhus tox. — Damp weather pains, > motion; lacks exact hour signature; use Cedron if storm-timed neuralgia occurs. [Boger]
• Gelsemium — Dull, lethargic intermittents; prostration > neural precision; Cedron is more acute, orbital, and exact. [Farrington]

General Headache Sets

• Iris versicolor — Frontal with bilious vomiting; weekly periodicity but food triggers dominate; Cedron if marsh and clock are louder. [Clarke]
• Nux vomica — Morning, business, coffee; irritable; periodicity looser; Cedron when coffee on the day sharpens the hour. [Kent]

• Complementary: China / Chininum sulph. — restore antiperiodic balance systemically after Cedron has broken the neural clock; or conversely begin with antiperiodic then finish neural focus. [Farrington], [Hale]
• Complementary: Spigelia — orbital ally; Spig. for motion-sensitive ciliary pains without strict hour; Cedron when chronometry dominates. [Farrington]
• Follows well: Gelsemium — after torpid intermittents lift, if a precise-hour brow pain persists. [Farrington], [Kent]
• Follows well: Eupatorium perf. — when bone-aches subside yet timed supra-orbital neuralgia continues. [Clarke]
• Precedes well: Natrum mur. — chronic intermittent constitution after Cedron cuts the acute time-lock; Nat-m. for long spleen/cephalic residua. [Farrington], [Clarke]
• Compare (venom sphere): Lachesis, Crotalus, Naja — for systemic venom states; Cedron remains the neuro-periodic antidotal tradition. [Clarke], [Hale]
• Related: Sanguinaria (weekly hemicrania), Iris (bilious), Belladonna (congestive) — choose by pattern (weekly/bilious/congestive) vs Cedron’s clock. [Clarke], [Kent]
• Antidotes / aggravations: Avoid coffee/alcohol near the hour; gentle heat, dark, pressure are temporising; abortive sleep may skip an attack (practical). [Allen], [Clarke]
• Inimical (functional): Overuse of quinine may blur the picture toward China; re-elicit Cedron by demonstrating the minute-exact neuralgia. [Hale], [Farrington]

• Clock-exact supra-orbital neuralgia (often left), weather-malarial history. Cedron 30C–200C at prodrome or night before the known hour; avoid coffee/alcohol; dark room, warm compress; if broken, do not repeat until pattern threatens to re-form. [Allen], [Clarke], [Farrington]
• Intermittent fever with fixed hour (quotidian/tertian/quartan). Dose at end of sweat and again preceding next expected hour; alternate-day scheduling may align with cycle in obstinate cases (clinical tradition). [Hale], [Clarke]
• Bites/stings with burning neuralgic tracks. Consider Cedron when timed neuralgias follow puncture injuries (adjunct to wound care and specific remedies). [Hale], [Clarke]
  Case pearls:
  • Left supra-orbital pain 5 p.m. daily, worsened in damp heat; ring to occiput; sweat ends attack. Cedron 200C at 3 p.m. × 2 days → hour drifted to 6:10, then ceased. [Clarke], [Allen]
  • Tertian ague at 10 a.m.; thirst before chill; orbital prodrome. Cedron 30C after sweat; next paroxysm skipped; convalescence with China. [Hale], [Farrington]
  • Scorpion sting; burning line up limb; nightly twinges at 9 p.m. Cedron 30C evening × 3; periodic twinge abolished. [Hale]

10 per section; one-line clinical note)

Mind

• Anxiety from anticipation of the fixed hour. Temporal fear guides to Cedron. [Clarke]
• Irritability before paroxysm; stoic during pain. Characteristic timeline. [Allen]
• Weather/storm foreboding increases unease. Meteorologic mind–body link. [Hale]
• Well between attacks; despondent when hour approaches. Interval wellness rubric. [Clarke]
• Aversion to conversation at the time. Economy of speech during pain. [Allen]
• Compulsive time-watching. Chronometric signature. [Clarke]

Head

• Neuralgia, supra-orbital, left (alternating), periodic to the minute. Grand keynote. [Allen], [Hering]
• Pain circles eye to temple/occiput (band-headache). Ring pathway rubric. [Clarke]
• Worse wind, light, jar; better tight band before, not during. Modal paradox recorded. [Allen]
• Headache preceding intermittent chill. Fever prodrome linkage. [Clarke]
• Headache returns same hour daily/tertiary/quartan. Cycle rubric. [Hale]
• Tingling scalp before attack. Prodrome sign. [Allen]

Eyes

• Ophthalmia, malarial; ciliary neuralgia with photophobia. Cedron setting. [Clarke]
• Lachrymation with supra-orbital pain. Reflex sign. [Allen]
• Worse sunrise/sunset. Light-transition cue. [Allen]
• Better in dark room. Palliative environment. [Allen]
• Intolerant of eye movements during the hour. Ciliary strain. [Allen]
• Pericorneal injection during paroxysm. Objective sign. [Clarke]

Fever/Chill/Heat/Sweat

• Intermittent fever at exact hour (quotidian/tertian/quartan). Cedron hallmark. [Hale], [Clarke]
• Thirst before chill; little during heat; sweat relieves. Stage-specific thirst. [Allen]
• Chill with supra-orbital pain. Prodrome anchor. [Clarke]
• Suppressed sweat prolongs paroxysm. Management pointer. [Clarke]
• Alternation with weather/marsh exposure. Geographic rubric. [Hale]
• Great prostration after sweat but mental relief. Cycle closure. [Clarke]

Generalities

• Periodicity—symptoms recur by the clock. Essence rubric. [Hering], [Clarke]
• Worse storms, damp heat, marshes; better dry air. Environmental axis. [Hale]
• Better between paroxysms; sudden collapse at hour. Temporal polarity. [Clarke]
• Sensitive to coffee/alcohol on attack day. Practical trigger. [Allen]
• Left-sided affinities (orbit/ovary) with alternation. Lateral nuance. [Allen]
• Sequence: neuralgia → chill → heat → sweat → relief. Cedron cycle. [Clarke]

Face/Teeth

• Face, left side, tic with brow neuralgia. Trigeminal spread. [Allen]
• Toothache, upper jaw, periodic at fixed hour. Dental clock echo. [Allen]
• Touch of eyebrow intolerable during attack. Physical confirm. [Allen]
• Heat of face during fever stage. Stage sign. [Clarke]
• Burning infra-orbital streaks. Venom-like neuralgia. [Hale]
• Jaw motion aggravates at the hour. Avoidance behaviour. [Allen]

Sleep

• Wakes just before the hour. Chronobiologic arousal. [Allen]
• Sleep after sweat refreshes. Restorative phase. [Clarke]
• Loss of sleep = worse next attack. Management cue. [Allen]
• Dreams of clocks/appointments. Mind–sleep resonance. [Clarke]
• Better early sleep pre-empting attack. Preventive tactic. [Allen]
• Cannot sleep during ring-pain despite fatigue. Insomnium doloris. [Allen]

Hering — The Guiding Symptoms of Our Materia Medica (1879): proving points; supra-orbital neuralgia; periodic hour exactness.
Allen, T. F. — Encyclopædia of Pure Materia Medica (1874–79): detailed symptomatology (head/eyes/fever); modality paradox at supra-orbital notch.
Clarke, J. H. — A Dictionary of Practical Materia Medica (1900): substance background; intermittent fevers; geographic/weather modalities; clinical cases.
Hale, E. M. — New Remedies: Clinical and Pharmacological (1864–1891): antiperiodic/bite traditions; dosing strategies around fixed hours; marsh/meteorologic notes.
Hughes, R. — A Cyclopædia of Drug Pathogenesy (1891–95): toxicology of Simaroubaceae bitters; vaso-motor/neurogenic interpretations.
Farrington, E. A. — Clinical Materia Medica (1887): comparisons—Spigelia, China/Chin-s., Nat-m., Eupatorium; selection by time vs. tissue profiles.
Kent, J. T. — Lectures on Materia Medica (1905): miasmatic colouring and micro-comparisons (Bell., Spig., Lach.).
Boericke, W. — Pocket Manual of Homœopathic Materia Medica (1906): succinct keynotes—supra-orbital periodicity; marsh/storm aggravation; practical modalities.
Boger, C. M. — Synoptic Key of the Materia Medica (1915): generalities—periodicity; weather/geographic influences; sequencing of fever.
Nash, E. B. — Leaders in Homœopathic Therapeutics (1899): intermittent fevers—leader remedies and differential logic.
Tyler, M. L. — Homoeopathic Drug Pictures (1942): case vignettes illustrating clock-regular neuralgias (interpretive).
Phatak, S. R. — Concise Materia Medica (1977): condensed keynotes—exact hour, ophthalmic neuralgia, weather damp/heat aggravations.